Simply shoot the enemies until Bob says 'Unholy Kind', then pause the game, and restart from the checkpoint. You will then enter a news screen where the camera angle is ahelicopter. Once you get his health down a certain amount, you must jump into his eye. This mode makes it so every hit is an instant kill against enemies. Note: This trick requires that the Heaven Or Hell difficulty is unlocked. You can get a few thousand Red Orbs every few minutes. Keep playing the secret mission, and restarting it before completing it to earn as You will get a lot of Red Orbs for completing most of it, and keep the Red Orbs you earned even if you restart it. Immediately before completing the secret mission, pause the game, and restart from the checkpoint.
Use the Aquila or Osiris with the Double Up ability to get through the vines. Look at the right wall of the new path for blue vines blocking the entrance. The secret mission door is located on the right side of the long hall that appears after using Demon Pull on a wall. Make sure you have a Copper key so you can enter the Taste Of Heaven secret mission. Start Mission 8: Eyeless on any difficulty.